Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene structure and organization of the human β‐secretase ( <i>BACE</i> ) promoter

1 Apr 2004

Abstract excerpt

The first step in the generation of the amyloid-beta peptide (Abeta) deposited in the brains of patients with Alzheimer's disease (AD) is the processing of the larger Abeta precursor protein (APP) by an integral membrane aspartyl protease named the beta-site APP-cleaving enzyme (BACE). We present the genomic organization of the BACE gene. BACE mRNAs are synthesized as nine exons and eight introns from a 30.6 kb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aluminum toxicity and tolerance in plants and animals
Share to Alzheimer's disease research and treatments
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15059975
DOI: 10.1096/fj.03-1378fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene structure and organization of the human β‐secretase ( <i>BACE</i> ) promoterPMID 15059975Read ↗

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1Semantic proximity Read ↗

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genesSemantic proximity Read ↗

Cloning and expression of the rat BACE1 promoterSemantic proximity Read ↗

Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s DiseaseSemantic proximity Read ↗

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesisSemantic proximity Read ↗

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.Semantic proximity Read ↗

Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.Semantic proximity Read ↗

The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequencesSemantic proximity Read ↗

Promoter polymorphisms which modulate BACE1 expression are associated with sporadic Alzheimer's disease.Semantic proximity Read ↗

Polymorphism in the BACE gene influences the risk for Alzheimer's disease.Semantic proximity Read ↗

<i>BACE</i> Maps to Chromosome 11 and a <i>BACE</i> Homolog, <i>BACE2</i> , Reside in the Obligate Down Syndrome Region of Chromosome 21Semantic proximity Read ↗

BACE1 Structure and Function in Health and Alzheimers DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.