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Article

Type 1 diabetes could begin with alterations in innate anti-viral immunity, which are already at this stage associated with HLA risk haplotypes.

Diabetes/metabolism research and reviews - 1 Oct 2023

Buschard Karsten, Jensen Mathias Høj, Krogvold Lars, Gerling Ivan C, Dahl-Jørgensen Knut, Pedersen Kristina, Haupt-Jorgensen Martin

Abstract excerpt

AIMS: To investigate if HLA risk haplotypes and HbA1c levels are associated with the expression levels of innate anti-viral immune pathway genes in type 1 diabetes. MATERIALS AND METHODS: We investigated RNA expression levels of innate anti-viral immune pathway genes in laser-dissected islets from two to five tissue sections per donor from the Diabetes Virus Detection study and the network of Pancreatic Organ...

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Share to Diabetes Mellitus, Type 1
Share to OAS1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Glycated Hemoglobin

Share to Haplotypes

Share to HLA Antigens

Share to Immunity, Innate

Share to Young Adult

Source

Identifiers

PMID: 37395313
DOI: 10.1002/dmrr.3678

Genes

OAS1
OAS2
OAS3
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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