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Article

Photosensitization of wild and mutant strains of Escherichia coli by meso-tetra (N-methyl-4-pyridyl)porphine.

Biochemical and biophysical research communications - 5 Mar 1999

Valduga G, Breda B, Giacometti G M, Jori G, Reddi E

Abstract excerpt

Wild type Escherichia coli cells as well as some mutant strains lacking specific DNA repair systems are efficiently killed upon visible light-irradiation after 5 min-incubation with meso-tetra(4N-methyl-pyridyl)porphine (T4MPyP). The presence of oxygen is necessary for cell photoinactivation. The porphyrin appears to exert its phototoxic activity largely by impairing some enzymic and transport functions at the...

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PMID: 10066427
DOI: 10.1006/bbrc.1999.0190

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