Article
The role of glutathione biosynthesis in heavy metal resistance in the fission yeast Schizosaccharomyces pombe.
FEMS microbiology reviews - 1 Aug 1994
Coblenz A, Wolf K
Abstract excerpt
Plants and the fission yeast Schizosaccharomyces pombe synthesize small cadmium-binding peptides, called phytochelatins, in response to cadmium. Derived from glutathione (GSH: gamma-Glu-Cys-Gly), they have the general structure (gamma-Glu-Cys)nGly, where n is 2-11. In order to study the biosynthesis of phytochelatins, we used the mutagen N-methyl-N'-nitro-N nitrosoguanidine (MNNG) to select mutants with a lowered...
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