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Article

EGFR tyrosine kinase domain mutations in human gliomas.

Neurology - 26 Apr 2005

Marie Y, Carpentier A F, Omuro A M P, Sanson M, Thillet J, Hoang-Xuan K, Delattre J-Y

Abstract excerpt

Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor effective in patients with lung cancer with mutations in exons 19 and 21 of the EGFR tyrosine kinase domain. In this study, the authors tested the presence of such mutations in 95 gliomas including glioblastomas, anaplastic oligodendrogliomas, and low-grade gliomas. No mutation was found, which suggests that the biology of EGFR in...

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Source

Identifiers

PMID: 15851741
DOI: 10.1212/01.WNL.0000158654.07080.B0

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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