Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

doi:10.1158/1078-0432.CCR-05-0421

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Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2005

Lassman Andrew B, Rossi Michael R, Raizer Jeffrey J, Razier Jeffrey R, Abrey Lauren E, Lieberman Frank S, Grefe Chelsea N, Lamborn Kathleen, Pao William, Shih Alan H, Kuhn John G, Wilson Richard, Nowak Norma J, Cowell John K, DeAngelis Lisa M, Wen Patrick, Gilbert Mark R, Chang Susan, Yung W A, Prados Michael, Holland Eric C

Abstract excerpt

PURPOSE: We investigated the molecular effect of the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib in vivo on all available tumors from patients treated on North American Brain Tumor Consortium trials 01-03 and 00-01 for recurrent or progressive malignant glioma. EXPERIMENTAL DESIGN: EGFR expression and signaling during treatment with erlotinib or gefitinib were analyzed by Western...

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PMID: 16278407
DOI: 10.1158/1078-0432.CCR-05-0421

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EGFR

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