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Epidermal Growth Factor Receptor and its Oncogenic EGFRvIII Variant in Benign and Malignant Brain Tumors.

Anticancer research - 1 Feb 2021

Kielbus Michal, Rola Radoslaw, Jarosz Bozena, Jeleniewicz Witold, Cybulski Marek, Stenzel-Bembenek Agnieszka, Podkowinski Arkadiusz, Smok-Kalwat Jolanta, Polberg Krzysztof, Trojanowski Tomasz, Stefaniuk Dawid, Stepulak Andrzej

Abstract excerpt

BACKGROUND/AIM: Tumorigenesis and cancer progression might be driven by abnormal activation of growth factor receptors. Importantly, molecular changes in EGFR-dependent signaling is one of the most common characteristics of brain tumors. PATIENTS AND METHODS: HER1 and EGFRvIII variants in meningiomas and glioblastomas were evaluated at the RNA level. RESULTS: EGFRvIII was found in 18.6% of glioblastomas (GBM),...

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PMID: 33517305
DOI: 10.21873/anticanres.14852

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