Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of B-RAF gene in human gliomas.

Acta neuropathologica - 1 Feb 2005

Basto Diana, Trovisco Vítor, Lopes José M, Martins Albino, Pardal Fernando, Soares Paula, Reis Rui M

Abstract excerpt

The RAS/RAF/MEK/ERK kinase pathway is pivotal in the transduction of mitogenic stimuli from activated growth factor receptors, which regulates cell proliferation, survival, and differentiation. Up-regulation of this pathway due to RAS mutations is found in approximately 30% of human tumors. Recently, activating mutations of B-RAF were identified in a large proportion of human cancers. Gliomas are the most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Blotting, Northern
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glioma

Share to Melanoma and MAPK Pathways

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 15791479
DOI: 10.1007/s00401-004-0936-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of B-RAF gene in human gliomas.PMID 15791479Read ↗

Targeting Ras-RAF-ERK and its Interactive Pathways as a Novel Therapy for Malignant GliomasSemantic proximity Read ↗

Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.Semantic proximity Read ↗

B-RAF mutations are a rare event in pituitary adenomas.Semantic proximity Read ↗

Adult classical glioblastoma with a BRAF V600E mutation.Semantic proximity Read ↗

RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations.Semantic proximity Read ↗

Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.Semantic proximity Read ↗

Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.Semantic proximity Read ↗

EGFR tyrosine kinase domain mutations in human gliomas.Semantic proximity Read ↗

High frequency of mutations in the PIK3CA gene helical and kinase coding regions in a group of Iranian patients with high-grade glioblastomas: five novel mutations.Semantic proximity Read ↗

Lack of B-RAF mutations in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT.Semantic proximity Read ↗

Constitutive activation of Raf-1 induces glioma formation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.