Article
A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2008
Pawlak Cornelius R, Sanchis-Segura Carles, Soewarto Dian, Wagner Sibylle, Hrabé de Angelis Martin, Spanagel Rainer
Abstract excerpt
The aim of this study was the application of a phenotype-driven N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice for the identification of dominant mutations involved in the regulation and modulation of alcohol-drinking behavior. The chemical mutagen ENU was utilized in the generation of 131 male ENU-mutant C57BL/6J mice (G0). These ENU-treated mice were paired with wild-type C57BL/6J mice to generate G1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.