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Article

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.

Neuron - 21 Apr 2005

Mehta Sunil Q, Hiesinger P Robin, Beronja Slobodan, Zhai R Grace, Schulze Karen L, Verstreken Patrik, Cao Yu, Zhou Yi, Tepass Ulrich, Crair Michael C, Bellen Hugo J

Abstract excerpt

The exocyst is a complex of proteins originally identified in yeast that has been implicated in polarized secretion. Components of the exocyst have been implicated in neurite outgrowth, cell polarity, and cell viability. We have isolated an exocyst component, sec15, in a screen for genes required for synaptic specificity. Loss of sec15 causes a targeting defect of photoreceptors that coincides with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15848801
DOI: 10.1016/j.neuron.2005.02.029

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Related research

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Research trail→

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Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.PMID 15848801Read ↗

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.Semantic proximity Read ↗

Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission.Semantic proximity Read ↗

Sec6 mutations and the Drosophila exocyst complex.Semantic proximity Read ↗

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.Semantic proximity Read ↗

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.Semantic proximity Read ↗

Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast.Semantic proximity Read ↗

Functional Analysis of the Exocyst Subunit Sec15 in Candida albicans.Semantic proximity Read ↗

Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.Semantic proximity Read ↗

Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.Semantic proximity Read ↗

Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants.Semantic proximity Read ↗

The rab exchange factor Sec2p reversibly associates with the exocyst.Semantic proximity Read ↗

The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary.Semantic proximity Read ↗

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