Article
The rab exchange factor Sec2p reversibly associates with the exocyst.
Molecular biology of the cell - 1 Jun 2006
Medkova Martina, France Y Ellen, Coleman Jeff, Novick Peter
Abstract excerpt
Activation of the rab GTPase, Sec4p, by its exchange factor, Sec2p, is needed for polarized transport of secretory vesicles to exocytic sites and for exocytosis. A small region in the C-terminal half of Sec2p regulates its localization. Loss of this region results in temperature-sensitive growth and the depolarized accumulation of secretory vesicles. Here, we show that Sec2p associates with the exocyst, an...
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