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Article

Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission.

Traffic (Copenhagen, Denmark) - 1 Dec 2002

Andrews Hillary K, Zhang Yong Q, Trotta Nick, Broadie Kendal

Abstract excerpt

The sec6/8, or exocyst, complex is implicated in trafficking of secretory vesicles to fusion sites in the plasma membrane. Genetic analyses have been done primarily in yeast, where mutation of the eight protein subunits similarly disrupts polarized vesicle fusion. The goal of this study was to assay the sec6/8 complex in Drosophila, and specifically to test its widely hypothesized functions in synaptogenesis and...

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Identifiers

PMID: 12453153
DOI: 10.1034/j.1600-0854.2002.31206.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission.PMID 12453153Read ↗

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Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.Semantic proximity Read ↗

Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast.Semantic proximity Read ↗

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.Semantic proximity Read ↗

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.Semantic proximity Read ↗

Anniversary of the discovery of sec mutants by Novick and Schekman.Semantic proximity Read ↗

The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary.Semantic proximity Read ↗

Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission.Semantic proximity Read ↗

Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.Semantic proximity Read ↗

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