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Article

Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.

FEBS letters - 1 Jul 2021

Ramesh Rashmi, Dautel Martina, Lee Yongook, Kim Yeonsoo, Storey Kirsty, Gottfried Susanne, Goss Kinzy Terri, Huh Won-Ki, Sattlegger Evelyn

Abstract excerpt

Eukaryotes harbour a conserved signalling pathway, called General Amino Acid Control (GAAC) in Saccharomyces cerevisiae, for overcoming amino acid starvation. Upon starvation, the protein kinase Gcn2, which phosphorylates the eukaryotic translation initiation factor eIF2α, becomes stimulated to trigger the GAAC response. Genetic studies suggest that Yih1, which is the yeast homolog of mammalian IMPACT and which...

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PMID: 34096057
DOI: 10.1002/1873-3468.14137

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Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.PMID 34096057Read ↗

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