The TOR signaling cascade regulates gene expression in response to nutrients.

doi:10.1101/gad.13.24.3271

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Article

The TOR signaling cascade regulates gene expression in response to nutrients.

Genes & development - 15 Dec 1999

Cardenas M E, Cutler N S, Lorenz M C, Di Como C J, Heitman J

Abstract excerpt

Rapamycin inhibits the TOR kinases, which regulate cell proliferation and mRNA translation and are conserved from yeast to man. The TOR kinases also regulate responses to nutrients, including sporulation, autophagy, mating, and ribosome biogenesis. We have analyzed gene expression in yeast cells exposed to rapamycin using arrays representing the whole yeast genome. TOR inhibition by rapamycin induces expression...

Topics

Culture Media
Cycloheximide
Drosophila Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genotype
Humans
Mitochondria
Nitrogen
Receptor Protein-Tyrosine Kinases
Ribosomal Proteins
Saccharomyces cerevisiae
Signal Transduction
Sirolimus
Transcription, Genetic

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Identifiers

PMID: 10617575
DOI: 10.1101/gad.13.24.3271
PMCID: PMC317202

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