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Article

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

The Journal of biological chemistry - 18 May 2001

Kubota H, Ota K, Sakaki Y, Ito T

Abstract excerpt

When starved for a single amino acid, the budding yeast Saccharomyces cerevisiae activates the eukaryotic initiation factor 2alpha (eIF2alpha) kinase GCN2 in a GCN1-dependent manner. Phosphorylated eIF2alpha inhibits general translation but selectively derepresses the synthesis of the transcription factor GCN4, which leads to coordinated induction of genes involved in biosynthesis of various amino acids, a...

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Source

Identifiers

PMID: 11350982
DOI: 10.1074/jbc.M011793200

Genes

GCN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.PMID 11350982Read ↗

GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.Semantic proximity Read ↗

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.Semantic proximity Read ↗

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.Semantic proximity Read ↗

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.Semantic proximity Read ↗

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.Semantic proximity Read ↗

Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.Semantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation.Semantic proximity Read ↗

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.Semantic proximity Read ↗

Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

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