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Article

The importance of modelling heterogeneity in complex disease: application to NIMH Schizophrenia Genetics Initiative data.

Human genetics - 1 Jul 2005

Holliday Elizabeth, Mowry Bryan, Chant David, Nyholt Dale

Abstract excerpt

As for other complex diseases, linkage analyses of schizophrenia (SZ) have produced evidence for numerous chromosomal regions, with inconsistent results reported across studies. The presence of locus heterogeneity appears likely and may reduce the power of linkage analyses if homogeneity is assumed. In addition, when multiple heterogeneous datasets are pooled, inter-sample variation in the proportion of linked...

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PMID: 15843988
DOI: 10.1007/s00439-005-1282-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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