Article
Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families.
Biological psychiatry - 15 Jul 2008
Fanous Ayman H, Neale Michael C, Webb Bradley T, Straub Richard E, O'Neill Francis A, Walsh Dermot, Riley Brien P, Kendler Kenneth S
Abstract excerpt
BACKGROUND: Several lines of evidence suggest that the clinical heterogeneity of schizophrenia is due to genetic heterogeneity. Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci. METHODS: Latent class analysis was used to divide...
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