Article
Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes.
Molecular psychiatry - 1 Nov 2000
Pulver A E, Mulle J, Nestadt G, Swartz K L, Blouin J L, Dombroski B, Liang K Y, Housman D E, Kazazian H H, Antonarakis S E, Lasseter V K, Wolyniec P S, Thornquist M H, McGrath J A
Abstract excerpt
Despite considerable effort to identify susceptibility loci for schizophrenia, none have been localized. Multiple genome scans and collaborative efforts have shown evidence for linkage to regions on chromosomes 1q, 5q, 6q, 8p, 13q, 10p and 22q.(1-9) Heterogeneity is likely. We previously mapped schizophrenia susceptibility loci (SSL) to chromosomes 13q32 (P = 0.00002) and 8p21-22 (P= 0.0001) using 54 multiplex...
Topics
- Family Health
- Genetic Heterogeneity
- Genetic Linkage
- Genome, Human
- Humans
- Phenotype
- Schizophrenia