Article
Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia.
Human heredity - 1 Jan 2010
Maher Brion S, Reimers Mark A, Riley Brien P, Kendler Kenneth S
Abstract excerpt
BACKGROUND/AIMS: Meta-analysis of genetic association studies is a useful approach when individual investigations do not yield studywise significant results but the evidence across studies is modest and homogeneous. Current meta-analysis methods account for heterogeneity by down-weighting studies as a function of between-study variance. We contend that current approaches may obscure interesting phenomena in...
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