Article
Colorectal cancer prognosis: is it all mutation, mutation, mutation?
Gut - 1 Sept 2005
Hassan A B, Paraskeva C
Abstract excerpt
For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall...
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