Article
Detection of APC and k-ras mutations in the serum of patients with colorectal cancer.
Cancer detection and prevention - 1 Jan 2001
Lauschke H, Caspari R, Friedl W, Schwarz B, Mathiak M, Propping P, Hirner A
Abstract excerpt
Detection of tumor DNA in peripheral blood of patients with colorectal cancer (CRC) may allow early diagnosis of tumor disease and be of prognostic value. However, a reliable tumor marker detectable in the serum of patients with this disease is missing. Because k-ras and APC mutations occur frequently and at an early stage in CRCs, these mutations might also be detected in the serum of CRC patients and serve as...
Topics
- Adenocarcinoma
- Base Sequence
- Biomarkers, Tumor
- Colorectal Neoplasms
- DNA, Neoplasm
- Genes, APC
- Genes, ras
- Humans
- Mutation
- Sequence Analysis, DNA