Article
Genetic association of a cathepsin D polymorphism and sporadic Creutzfeldt-Jakob disease.
Dementia and geriatric cognitive disorders - 1 Jan 2009
Jeong Byung-Hoon, Lee Kyung-Hee, Lee Yun-Jung, Yun Jisuk, Park Young-Jae, Bae Yoonsang, Kim Young-Hoon, Cho Young-Sook, Choi Eun-Kyoung, Carp Richard I, Kim Yong-Sun
Abstract excerpt
BACKGROUND: Cathepsin D is the most abundant lysosomal and endosomal aspartyl protease; it shows beta and gamma secretase activity in vitro by cleaving the amyloid precursor protein into amyloid beta protein. In recent studies, cathepsin D was co-localized with PrP(Sc), the disease-associated form of the prion disease, and abnormal expression of cathepsin D correlated with tissue damage in brains of sporadic...
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