Article
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.
Acta neurologica Scandinavica - 1 Jun 2011
Jeong B-H, Lee K-H, Lee Y-J, Yun J, Park Y-J, Kim Y-H, Cho Y-S, Choi E-K, Carp R I, Kim Y-S
Abstract excerpt
BACKGROUND: Cathepsin D, the most abundant lysosomal and endosomal aspartyl protease, shows beta and gamma secretase activity in vitro by cleaving the amyloid precursor protein (APP) into amyloid beta protein (Aβ). Polymorphism at position 224, C224T, on exon 2 of cathepsin D gene (CTSD) has been associated with an increased risk for Alzheimer's disease (AD) by some investigators, but there have been contrary...
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