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Article

A functional interleukin-10 mutation in Dutch patients with Crohn's disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 May 2005

van der Linde K, Boor P P C, van Bodegraven A A, de Jong D J, Crusius J B A, Naber T H J, Kuipers E J, Wilson J H P, de Rooij F W M

Abstract excerpt

BACKGROUND AND AIMS: Interleukin-10 is an anti-inflammatory and immunomodulatory cytokine. Interleukin-10 deficient mice are prone to develop chronic colitis. Administration of recombinant human interleukin-10 has been proposed to have a beneficial effect in a subgroup of patients with Crohn's disease. Recently, we found an interleukin-10 Gly15Arg mutation in a family with Crohn's disease which is associated with...

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PMID: 15843082
DOI: 10.1016/j.dld.2004.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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