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Polymorphisms in interleukin-10 gene according to mutations of NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn's disease.

World journal of gastroenterology - 21 Jan 2006

Mendoza Juan L, Urcelay Elena, Lana Raquel, Martinez Alfonso, Taxonera Carlos, de la Concha Emilio G, Díaz-Rubio Manuel

Abstract excerpt

AIM: To examine the contribution of interleukin-10 (IL-10) gene polymorphisms to Crohnos disease (CD) phenotype, and the possible genetic epistasis between IL-10 gene polymorphisms and CARD15/NOD2 gene mutations. METHODS: A cohort of 205 Spanish unrelated patients with Crohn's disease recruited from a single center was studied. All patients were rigorously phenotyped and followed-up for at least 3 years (mean...

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Identifiers

PMID: 16489646
DOI: 10.3748/wjg.v12.i3.443
PMCID: PMC4066065

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NOD2

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