Article
Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.
Scandinavian journal of gastroenterology - 1 Dec 2006
Seiderer Julia, Schnitzler Fabian, Brand Stephan, Staudinger Tanja, Pfennig Simone, Herrmann Karin, Hofbauer Katrin, Dambacher Julia, Tillack Cornelia, Sackmann Michael, Göke Burkhard, Lohse Peter, Ochsenkühn Thomas
Abstract excerpt
OBJECTIVE: The identification of CARD15 as a susceptibility gene for Crohn's disease (CD) offers new possibilities for patient classification and risk assessment. The purpose of this study was to carry out a CARD15 sequence analysis in a large single-center IBD cohort and to investigate the impac...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.