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Article

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

The Journal of clinical investigation - 1 Apr 2005

Choudhury Agharul I, Heffron Helen, Smith Mark A, Al-Qassab Hind, Xu Allison W, Selman Colin, Simmgen Marcus, Clements Melanie, Claret Marc, Maccoll Gavin, Bedford David C, Hisadome Kazunari, Diakonov Ivan, Moosajee Vazira, Bell Jimmy D, Speakman John R, Batterham Rachel L, Barsh Gregory S, Ashford Michael L J, Withers Dominic J

Abstract excerpt

Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons (POMCCreIrs2KO) to determine the role of Irs2 in the CNS and beta cell. RIPCreIrs2KO mice displayed impaired glucose tolerance and reduced beta cell mass. Overt diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin Receptor Substrate Proteins

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Source

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Identifiers

PMID: 15841180
DOI: 10.1172/JCI24445
PMCID: PMC1069106

Genes

POMC
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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