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Article

Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.

Scientific reports - 2 Feb 2016

Li Ling, Gao Lin, Wang Kejia, Ma Xianhua, Chang Xusheng, Shi Jian-Hui, Zhang Ye, Yin Kai, Liu Zhimin, Shi Yuguang, Xie Zhifang, Zhang Weiping J

Abstract excerpt

The recombination efficiency and cell specificity of Cre driver lines are critical for exploring pancreatic β cell biology with the Cre/LoxP approach. Some commonly used Cre lines are based on the short Ins2 promoter fragment and show recombination activity in hypothalamic neurons; however, whether this stems from endogenous Ins2 promoter activity remains controversial. In this study, we generated Ins2-Cre...

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Identifiers

PMID: 26830324
DOI: 10.1038/srep20438
PMCID: PMC4735843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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