Article

Loss of brain insulin production impairs learning and memory in female mice

2025-08-21

Abstract excerpt

Diabetes is characterized by dysfunctional insulin release and action, and it is a risk factor for Alzheimer’s disease, the most common form of dementia. Alterations in brain insulin signalling and metabolism have been linked with Alzheimer’s disease. The ancestral insulin gene, Ins2 , is transcribed locally within the brain. Here we demonstrate that hippocampal Ins2 mRNA is higher in females than males, and mod...

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Literature Corpus work: 6cebee1b-3ee0-592d-b463-c959f464ec57
DOI: 10.1101/2025.08.15.670639

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