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Article

Cellular Origin of Human B-Cell Lymphomas

11 Nov 1999

Abstract excerpt

The origin of human lymphomas has been studied by various approaches, including histology and immunophenotyping. In some types of lymphoma these studies suggested the cellular origin, but in many instances the origin could not be identified. When somatic mutations of the genes for the variable region of the B-lymphocyte antigen receptor proved to be a hallmark of germinal-center B cells and their descendants,...

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PMID: 10559454
DOI: 10.1056/nejm199911113412007

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