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Article

Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect.

The Journal of biological chemistry - 17 Jun 2005

Kim Yong, Ohyama Hiroe, Patel Vipel, Figueiredo Marxa, Wong David T

Abstract excerpt

p12(CDK2-AP1) (p12) is a CDK2-associated protein that negatively regulates its kinase activity. Growth arrest of normal diploid cells by contact inhibition resulted in an induction of p27(kip1) and reduction of CDK2 levels. Interestingly, we observed concomitantly in growth-arrested cells, there was a reduction of nuclear p12 and the appearance of a nuclear 25-kDa molecule (p25) recognized by anti-p12 polyclonal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15840587
DOI: 10.1074/jbc.M412929200

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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