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Article

Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.

The Journal of biological chemistry - 31 May 2002

Wang Ziqiu, Wang Meifang, Lazo John S, Carr Brian I

Abstract excerpt

Cdc25A, a dual-specificity protein phosphatase, plays a critical role in cell cycle progression. Although cyclin-dependent kinases are established substrates, Cdc25A may also affect other proteins. We have shown here that Cdc25A interacts with epidermal growth factor receptor (EGFR) both physically and functionally in Hep3B human hepatoma cells. Cdc25A inhibitor Cpd 5, a vitamin K analog, inhibited Cdc25A...

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Source

Identifiers

PMID: 11912208
DOI: 10.1074/jbc.M201097200

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.PMID 11912208Read ↗

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CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic StabilitySemantic proximity Read ↗

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Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast CancerSemantic proximity Read ↗

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Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.Semantic proximity Read ↗

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