Article
The N-terminal 15-48 region of cyclin kinase inhibitor p21 is a determinant of basal expression.
Cancer genomics & proteomics - 1 Jan 2000
Nomura Norihiro, Yamaguchi Fumihiro, Fukuchi Kunihiko
Abstract excerpt
The cyclin kinase inhibitor, p21, inhibits or arrests cell cycle progression in response to DNA damage and regulates the progression of apoptosis, either negatively or positively depending on the situation. The stability of p21 is regulated by its phosphorylation or through binding with partner molecules, and, when cells grow without DNA damage, the level of p21 is regulated by proteasome degradation. In this...
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