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Article

Viral cyclin promotes KSHV-induced cellular transformation and tumorigenesis by overriding contact inhibition.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Jones Tiffany, Ramos da Silva Suzane, Bedolla Roble, Ye Fengchun, Zhou Fuchun, Gao Shou-Jiang

Abstract excerpt

Kaposi sarcoma-associated herpesvirus (KSHV) is a tumor virus encoding several proto-oncogenes. However, the roles of these viral genes in KSHV-induced tumorigenesis have not been defined. In this study, we used a recently developed model of KSHV-induced cellular transformation and tumorigenesis combining with a reverse genetic system to examine the role of a KSHV latent gene vCyclin (ORF72), a cellular Cyclin D2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24419204
DOI: 10.4161/cc.27758
PMCID: PMC3979920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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