Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.

Toxicology - 1 Jun 2005

Kim Jin Sik, Kim Yang Jee, Kim Tae Yon, Song Joo Young, Cho Yoon Hee, Park Yeong Chul, Chung Hai Won

Abstract excerpt

To investigate whether sensitivity to the induction of micronuclei by acetaldehyde is associated with genetic polymorphisms of the aldehyde dehydrogenase-2 (ALDH2) gene, cytokinesis-block micronucleus (CBMN) assays were performed on peripheral lymphocytes from 47 healthy human subjects exposed to acetaldehyde in vitro. Facial flushing following alcohol intake was analyzed to determine if it was correlated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to Alcohol Drinking

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Flushing

Share to Homozygote

Share to Lymphocytes

Share to Micronuclei, Chromosome-Defective

Source

Identifiers

PMID: 15840430
DOI: 10.1016/j.tox.2005.01.016

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.PMID 15840430Read ↗

Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms.Semantic proximity Read ↗

Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde.Semantic proximity Read ↗

Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism.Semantic proximity Read ↗

Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach.Semantic proximity Read ↗

Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.Semantic proximity Read ↗

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.Semantic proximity Read ↗

Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers.Semantic proximity Read ↗

Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans.Semantic proximity Read ↗

Evaluation of the use of self-reported facial flushing and ethanol patch test for ALDH2 genotypes.Semantic proximity Read ↗

Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.Semantic proximity Read ↗

Alcohol flushing, patch test, and ADH and ALDH genotypes in Brazilian ethnic groups.Semantic proximity Read ↗

An examination of ALDH2 genotypes, alcohol metabolism and the flushing response in Native Americans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.