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Article

Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009

Boccia Stefania, Hashibe Mia, Gallì Paola, De Feo Emma, Asakage Takahiro, Hashimoto Tomoko, Hiraki Akio, Katoh Takahiko, Nomura Takeshi, Yokoyama Akira, van Duijn Cornelia M, Ricciardi Gualtiero, Boffetta Paolo

Abstract excerpt

Alcohol drinking at high doses is a risk factor for head and neck cancer, and exposure to acetaldehyde, the principle metabolite of alcohol, is supposed to account for the increased risk. Individuals homozygous for the 2 variant allele of aldehyde dehydrogenase 2 (ALDH2) are unable to metabolize...

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Source

Identifiers

PMID: 19124505
DOI: 10.1158/1055-9965.EPI-08-0462

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19124505-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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