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Article

Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde.

The Journal of toxicological sciences - 1 Feb 2008

Kunugita Naoki, Isse Toyohi, Oyama Tsunehiro, Kitagawa Kyoko, Ogawa Masanori, Yamaguchi Tetsunosuke, Kinaga Tsuyoshi, Kawamoto Toshihiro

Abstract excerpt

Aldehyde dehydrogenase-2 (ALDH2) metabolizes acetaldehyde produced from ethanol into acetate and plays a major role in the oxidation of acetaldehyde in vivo. About half of all Japanese people have inactive ALDH2. We generated homozygous Aldh2 null (Aldh2-/-) mice by gene targeting knockout as a model of ALDH2-deficient humans. To investigate the mutagenicity of acetaldehyde, a micronucleus assay and a T-cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Micronuclei, Chromosome-Defective

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Source

Identifiers

PMID: 18303182
DOI: 10.2131/jts.33.31

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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