Article
Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers.
Alcoholism, clinical and experimental research - 1 Apr 2005
Yokoyama Tetsuji, Saito Kyoko, Lwin Htay, Yoshiike Nobuo, Yamamoto Akio, Matsushita Yumi, Date Chigusa, Tanaka Heizo
Abstract excerpt
BACKGROUND: Elevated mean corpuscular volume (MCV) is a traditional biological marker for alcohol abuse and alcoholism, but the underlying mechanism is unclear. Three recent epidemiologic studies consistently showed that MCV was elevated by alcohol drinking more markedly among individuals with genetically inactive aldehyde dehydrogenase-2 (ALDH2) (encoded by ALDH2*2 mutant allele) than those with active ALDH2...
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