Article
Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism.
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence - 1 Feb 1993
Yamamoto K, Ueno Y, Mizoi Y, Tatsuno Y
Abstract excerpt
Influence of genetic polymorphism at the alcohol dehydrogenase2 (ADH2) and aldehyde dehydrogenase2 (ALDH2) loci on ethanol elimination and blood acetaldehyde level was studied in healthy subjects. Polymorphic regions of the ADH2 and ALDH2 genes were amplified for genomic DNA by using the technique of polymerase chain reaction. The ADH2 genotype was determined by digestion with the restriction enzyme MaeIII and...
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