Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.

doi:10.1111/j.1349-7006.2010.01599.x

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Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.

Cancer science - 1 Aug 2010

Oze Isao, Matsuo Keitaro, Hosono Satoyo, Ito Hidemi, Kawase Takakazu, Watanabe Miki, Suzuki Takeshi, Hatooka Shunzo, Yatabe Yasushi, Hasegawa Yasuhisa, Shinoda Masayuki, Tajima Kazuo, Tanaka Hideo

Abstract excerpt

Some Japanese exhibit facial flushing after drinking alcohol. Facial flushing was considered to be caused by acetaldehydemia. The concentration of blood acetaldehyde was concerned with the catalytic activity of acetaldehyde dehydrogenase (ALDH). Acetaldehyde dehydrogenase (ALDH)-2 polymorphism (rs671, Glu504Lys) was known to be associated with upper aerodigestive tract (UAT) cancer due to modulation of ALDH2...

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Identifiers

PMID: 20518787
DOI: 10.1111/j.1349-7006.2010.01599.x
PMCID: PMC11159847

Genes

ALDH2

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