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Brucella abortus deficient in copper/zinc superoxide dismutase is virulent in BALB/c mice.

Microbial pathogenesis - 1 Feb 1992

Latimer E, Simmers J, Sriranganathan N, Roop R M, Schurig G G, Boyle S M

Abstract excerpt

The gene encoding the Cu/Zn superoxide dismutase (SOD) of Brucella abortus strain 2308 was identified in a Brucella genomic library utilizing a combination of Western blotting and native gel electrophoresis. The Cu/Zn SOD gene was inactivated in vitro by ligation of a kanamycin resistance gene into the open reading frame encoding SOD. The plasmid born construct was introduced back into B. abortus by...

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PMID: 1584004
DOI: 10.1016/0882-4010(92)90113-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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