Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene.

doi:10.1016/j.exppara.2007.05.005

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Article

Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene.

Experimental parasitology - 1 Dec 2007

Barrio Alejandra B, Van Voorhis Wesley C, Basombrío Miguel A

Abstract excerpt

Calmodulin-ubiquitin (cub) is a single-copy gene of Trypanosoma cruzi, which encodes a 208 aminoacid polypeptide of unknown function, containing putative calcium-binding domains. After targeted deletion, a clone (TulCub8) was derived where one of the two alleles was disrupted. This clone displayed a sharp and stable loss of virulence for mice. Parasitemias after inoculation of 10(6) trypomastigotes of the mutant,...

Topics

Alleles
Animals
Animals, Newborn
Blotting, Southern
Calmodulin
Electroporation
Female
Gene Deletion
Genetic Complementation Test
Mice
Mice, Inbred BALB C
Multigene Family
Transfection
Trypanosoma cruzi
Ubiquitin
Virulence

Source

Open in PubMed

Identifiers

PMID: 17624327
DOI: 10.1016/j.exppara.2007.05.005

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