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Article

Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene.

Experimental parasitology - 1 Dec 2007

Barrio Alejandra B, Van Voorhis Wesley C, Basombrío Miguel A

Abstract excerpt

Calmodulin-ubiquitin (cub) is a single-copy gene of Trypanosoma cruzi, which encodes a 208 aminoacid polypeptide of unknown function, containing putative calcium-binding domains. After targeted deletion, a clone (TulCub8) was derived where one of the two alleles was disrupted. This clone displayed a sharp and stable loss of virulence for mice. Parasitemias after inoculation of 10(6) trypomastigotes of the mutant,...

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Identifiers

PMID: 17624327
DOI: 10.1016/j.exppara.2007.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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