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Role of <i>Mycobacterium tuberculosis</i> Copper-Zinc Superoxide Dismutase

1 Jan 2001

Abstract excerpt

Superoxide dismutases (SODs) play an important role in protection against oxidative stress and have been shown to contribute to the pathogenicity of many bacterial species. To determine the function of the mycobacterial copper and zinc-cofactored SOD (CuZnSOD), we constructed and characterized Mycobacterium tuberculosis and Mycobacterium bovis BCG CuZnSOD null mutants. Both strains were more sensitive to...

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PMID: 11119546
DOI: 10.1128/iai.69.1.529-533.2001

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