Article
EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2005
Sasaki Hidefumi, Endo Katsuhiko, Konishi Akimitsu, Takada Minoru, Kawahara Masaaki, Iuchi Keiji, Matsumura Akihide, Okumura Meinoshin, Tanaka Hisaichi, Kawaguchi Tomoya, Shimizu Toshiki, Takeuchi Hiroshi, Yano Motoki, Fukai Ichiro, Fujii Yoshitaka
Abstract excerpt
PURPOSE: Recently, somatic mutations of the epidermal growth factor receptor (EGFR) gene were found in approximately 25% of Japanese lung cancer patients. These EGFR mutations are reported to be correlated with clinical response to gefitinib therapy. However, DNA sequencing using the PCR methods described to date is time-consuming and requires significant quantities of DNA; thus, this existing approach is not...
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