Article
Comparison of the Analytical Performance Between cobas EGFR Assay and PCR-Clamp Method in the Detection of EGFR Mutations in Japanese Non-Small Cell Lung Cancer Patients.
Clinical laboratory - 1 May 2017
Ai Tomohiko, Yuri Maiko, Tabe Yoko, Kakimoto Atsushi, Morishita Soji, Tsuchiya Koji, Takamochi Kazuya, Kodama Yuzo, Takahashi Fumiyuki, Shigeki Misawa, Horii Takashi, Suzuki Kenji, Takahashi Kazuhisa, Miida Takashi, Ohsaka Akimichi
Abstract excerpt
BACKGROUND: EGFR, a tyrosine-kinase, plays an important role in the progression of lung cancer. Since genetic abnormality of EGFR alters the effects of tyrosine-kinase inhibitors targeting EGFR, molecular analyses of EGFR have recently gained more attention in the treatment of lung cancer. However, several different techniques are available and which method is superior has not been determined. In this study, we...
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