Article
Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler.
Oncology reports - 1 Sept 2007
Sasaki Hidefumi, Okuda Katsuhiro, Kawano Osamu, Endo Katsuhiko, Yukiue Haruhiro, Yokoyama Tomoki, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
Activating mutations of Ras gene families have been found in a variety of human malignancies, including lung cancer, suggesting their dominant role in tumorigenesis. Many studies have showed that the Kras gene is activated by point mutations in approximately 15-20% of non-small cell lung cancers (NSCLCs), however, there are only a few reports on Nras mutations in NSCLC. We have genotyped Nras mutation status...
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