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Article

PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2006

Schönleben Frank, Qiu Wanglong, Ciau Nancy T, Ho Daniel J, Li Xiaojun, Allendorf John D, Remotti Helen E, Su Gloria H

Abstract excerpt

PURPOSE: Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic-alpha (PIK3CA) gene in various human solid tumors. More than 75% of those somatic mutations are clustered in the helical (exon 9) and kinase domains (exon 20). The three hot-spot mutations, E542K, E545K, and H1047R, have been proven to elevate the lipid kinase activity of PIK3CA and activate the...

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Identifiers

PMID: 16778113
DOI: 10.1158/1078-0432.CCR-06-0292
PMCID: PMC1780026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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