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Article

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions.

Shock (Augusta, Ga.) - 1 May 2005

Scott Melanie J, Liu Shubing, Su Grace L, Vodovotz Yoram, Billiar Timothy R

Abstract excerpt

The response to lipopolysaccharide (LPS) in the liver is complex, requiring cell-to-cell interactions between hepatocytes and liver nonparenchymal cells (NPC), in particular, Kupffer cells. Previous studies show that cytokines produced by Kupffer cells stimulated with LPS can, in turn, activate hepatocytes. In the present study, we sought to examine whether the reverse, hepatocyte (HC)-NPC interactions, is...

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PMID: 15834312
DOI: 10.1097/01.shk.0000160939.08385.f1

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LBP
TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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