Article

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

2025-07-11

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the preclinical models, resulting in therapy failure. Liver immune responses are strictly regulated by the interactions between hepatocytes and non-parenchymal liver cells, such as Kupffer cells (the liver-resident macrophages) but how rAA...

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Literature Corpus work: 833a3693-c875-5afe-96bb-3bb6354cba2a
DOI: 10.1101/2025.07.08.663523

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