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Article

Hepatic stellate cells induce an inflammatory phenotype in Kupffer cells via the release of extracellular vesicles.

Journal of cellular physiology - 1 Oct 2023

Geng Yana, Wang Junyu, Serna-Salas Sandra Alejandra, Villanueva Alejandra Hernández, Buist-Homan Manon, Arrese Marco, Olinga Peter, Blokzijl Hans, Moshage Han

Abstract excerpt

Liver fibrosis is the response of the liver to chronic liver inflammation. The communication between the resident liver macrophages (Kupffer cells [KCs]) and hepatic stellate cells (HSCs) has been mainly viewed as one-directional: from KCs to HSCs with KCs promoting fibrogenesis. However, recent studies indicated that HSCs may function as a hub of intercellular communications. Therefore, the aim of the present...

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Identifiers

PMID: 37555553
DOI: 10.1002/jcp.31086

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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